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The greatest concern regarding the synthetic
cannabinoids is their continuous change of structure.
While the initially manufactured drugs mostly include
JWH-018 and JWH-073, due to close regulations and
safety restrictions, a large amount of side-products
started to be produced (JWH-081, JWH-122, LWH210, and AM-2201). According to the report by the
European Monitoring Centre for Drugs and Drug
Addiction in 2012, out of the 73 psychoactive
chemicals, 30 were synthetic cannabinoids.
The drug has many harmful side effects including nausea,
vomiting, diffuse alveolar damage, tachycardia,
abdominal pain and edema. Many patients suffer
neuropsychiatric complaints. These neurologic
symptoms and findings may include ataxia, coma,
confusion, imbalance, headache, muscle weakness,
speech impairment, paralysis, epileptic seizure,
tremor, dilated pupils and nystagmus.
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The synthetic alternatives have then started to spread rapidly
because of their cheapness and commercial
availability. This synthetic form of the drug has many
different names in different countries. The drug is
most commonly referred as “Bonsai” in Turkey,
“Spice” in UK and “K2” or “Jamaica” in the US. The
synthetic cannabinoids are mainly smoked using a
pipe, a hookah (or a bong), or wrapped in cigarette
papers. There are many reports of the synthetic drug
taken orally as an alternative


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